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This sort of sequel to the film Knocked Up focuses on the life of the previous films supporting characters Pete (Paul Rudd) and Debbie (Leslie Mann). No longer worried about her sister, Debbie's concerns have now turned to turning the big 4-0. This midlife crisis leads to her questioning the foundry of her relationship with Pete, who also has to face his own problems on top of his emotional wife. What in the world is going to happen?
Albert Brooks , Billie Joe Armstrong , Charlyne Yi , Chris O'Dowd , Derek Basco , Erica Vittina Phillips , Gerald Emerick , Jason Segel , Jessica Lee , Joanne Baron , John Lithgow , Kristin Quick , Lena Dunham , Leslie Mann , Lisa Darr , Megan Fox , Melissa McCarthy , Michael Ian Black , Paul Rudd , Phil Burke , Phil Hendrie , Robert McMurrer , Robert Smigel , Ryan Lee , Suzy